Statistics remain one of the most overused, misunderstood, and misinterpreted aspects of conveying research to the general public. We have seen, in today’s world, how framing information can skew perceptions. By presenting and using statistics to “prove” or “disprove” a point (health related, political, or research focused), the same data set can be used to argue diametrically opposed conclusions. This issue of Annals looks at statistics from a number of vantage points. To begin, we frame the issue with the American Statistical Association’s (ASA) statement on p-values. The editorial and statement begins with...